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Accueil > La recherche > Département Bioingénierie > Biomicrosystèmes, Bioélectrochimie et Bioélectromagnétisme > Axe Microsystèmes

Permanent assembly of micro and nano-objects

par Naoufel - publié le

We use electromagnetic forces to handle non-contact Micro and dielectric and magnetic nanoparticles and biological cells. Depending on the nature of particles manipulated, we use dielectrophoresis, magnetophoresis or acoustic waves to assemble particles in an organized way and connect them permanently with coupling agents.

Photos of liposomes and dielectric particles assembled by dielectrophoresis

New generation of electrochemical biosensor based on permanent magnetic filaments

We are studying a new configuration of electrochemical biosensors by developing a new technological approach to immobilize a large number of biomolecular probes onto a transduction support. This approach is based on anchoring of magnetic particle filaments onto transduction support permitting, in a second step, thanks to the high surface to volume ratio of anchored filaments, to immobilize a large quantity of biological probes onto transduction surfaces. Furthermore, orientation properties of anchored filaments under magnetic field could be exploited to provide dynamism to the immobilization support and improve recognition of biological targets.

Schematic representation of magnetic filaments assembled and attached onto the electrode surface for immobilization of biological receptors.

This last project is carried out with Chemistry and Nanobiotechnology team of the Nanotechnology Institute of Lyon (INL).

Haddour, N. ; Chevolot, Y. ; Trévisan, M. ; Souteyrand, E. ; Cloarec, J.-P., "Use of magnetic field for addressing, grafting on support and actuating permanent magnetic filaments applied to enhanced biodetection." Journal of Materials Chemistry 2010, 20, 8266-8271. Lien